Table 1. Baseline characteristics of reports on vaccine-associated cirAEs. (n= 8,354)

Variables Number (%)
Region reporting African region 43 (0.51)
Region of the Americas 5,210 (62.37)
Southeast Asia region 52 (0.62)
European region 2,277 (27.26)
Eastern Mediterranean region 35 (0.42)
Western Pacific region 737 (8.82)
Reporting year 1968-1979 16 (0.19)
1980-1989 103 (1.23)
1990-1999 242 (2.90)
2000-2009 426 (5.10)
2010-2019 4,244 (50.8)
2020-2024 3,323 (39.78)
Reporter qualification Health professional 2,489 (29.79)
Non-health professional 450 (5.39)
Sex Male 4,083 (48.87)
Female 4,070 (48.72)
Unknown 201 (2.41)
Age, years 0 to 11 3,897 (46.65)
12 to 17 344 (4.12)
18 to 44 1,426 (17.07)
45 to 64 987 (11.81)
≥65 790 (9.46)
Unknown 910 (10.89)
TTO, days Median days (IQR) 1 (1-1)
Drug class Anthrax vaccines 41 (0.49)
Cholera vaccines 1 (0.01)
DTaP-IPV-Hib vaccines 1,789 (21.41)
Meningococcal vaccines 240 (2.87)
Pneumococcal vaccines 619 (7.41)
Tuberculosis vaccines 9 (0.11)
Typhoid vaccines 50 (0.60)
Encephalitis vaccines 51 (0.61)
Influenza vaccines 611 (7.31)
Hepatitis A vaccines 210 (2.51)
Hepatitis B vaccines 389 (4.66)
MMR vaccines 810 (9.70)
Rotavirus diarrhea vaccines 157 (1.88)
Zoster vaccines 407 (4.87)
Papillomavirus vaccines 150 (1.80)
COVID-19 mRNA vaccines 2,340 (28.01)
Ad5-vectored COVID-19 vaccines 248 (2.97)
Inactivated whole-virus COVID-19 vaccines 24 (0.29)
Other viral vaccines* 122 (1.46)
Others** 86 (1.03)
Fatal outcomes Recovered 4,216 (50.47)
Not recovered 827 (9.90)
Fatal 27 (0.32)
Death 3 (0.04)
Unknown 3,281 (39.27)
Single drug suspected 8,354 (100.00)
Abbreviation: cirAEs, cutaneous immune-related adverse events; DTaP-IPV-Hib, diphtheria, tetanus toxoids, pertussis, polio, and Hemophilus influenza type b; IQR, interquartile range; MMR, measles, mumps, and rubella; TTO, time to onset; WHO, World Health Organization.
Other viral vaccines: Dengue virus, Ebola, enterovirus 71, monkeypox, respiratory syncytial virus, and smallpox vaccines
Others: Brucellosis, leptospirosis, plague, and yellow fever vaccines.